Coordination of clinical trials, translational activities, and development of GMP procedures for cell-based therapeutic approaches and diagnostic tests

Project Z2

Project leaders:

Prof. Dr. med. Petra Reinke

CharitéUniversitätsmedizin Berlin

CVK: Campus Virchow-Klinikum

Medizinische Klinik für Nephrologie und Intensivmedizin und BCRT

13353 Berlin

t: +49 30 450 553 370

f: +49 30 450 553916

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Links:

Prof. Dr. med. Hans-Dieter Volk

CharitéUniversitätsmedizin Berlin

CVK: Campus Virchow-Klinikum

Institut für Medizinische Immunologie und BCRT

Postal address:

Augustenburger Platz 1

13353 Berlin

t: +49 30 450 524 062

f: +49 30 450 524932

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Links:

Summary

The project aims to prepare a road-map for developing cell-based therapies. The key achievements are: i) set of well standardized bomarkers for monitoring (safety, therapy response, patient stratification, mode-of-action), ii) advanced preclinical transplant models, iii) GMP protocols for nTreg enrichment/expansion, and iv) approved GMP-cell manufactoring lab. For the next funding period we will a) further validate the biomarkers, b) study the mode-of-action of nTreg, c) perform two clinical Proof-of-concept trials on nTreg in transplant patients, and d) support other SFB projects in preparing innovative trials.

Research Database

For more details please use the Charité undefinedresearch database.