Redirecting the antigen-specificity of polyclonal regulatory T cells to optimize their therapeutic efficacy and safety

Project 26

Project leaders:

Dr. rer. nat. Simon Fillatreau

Deutsches Rheuma-Forschungszentrum

Postal address:

Charitéplatz 1

10117 Berlin

t: +49 30 28460 761

f: +49 30 28460 604

Links:

Prof. Dr. rer. nat Alexander Scheffold

CharitéUniversitätsmedizin Berlin

CCM: Campus Charité Mitte

Med. Klinik m. S. Rheumatologie und Klin. Immunologie

Postal address:

Charitéplatz 1

10117 Berlin

t: +49 30 450 513 450

Links:

Prof. Dr. rer. nat. Wolfgang Uckert

Max-Delbrück Center

CBB: Campus Berlin Buch

Molecular Cell Biology and Gene Therapy

Postal address:

Robert-Rössle-Str. 10

13092 Berlin

t: +49 30 9406 3196

f: +49 30 94063306

Links:

Summary

Antigen-specific natural regulatory T cells (Tregs) can effectively suppress unwanted immunity. We established a T cell receptor (TCR) gene transfer protocol to turn polyclonal Tregs into antigen-specific Tregs that protected recipient mice from autoimmunity upon adoptive transfer. We will now prepare the translation of this approach to the clinic by examining which characteristics of the grafted antigen-specific receptor affect the function of Tregs, and by establishing good manufacturing practice compatible protocols for the manipulation of polyclonal human Tregs.

Research Database

For more details please use the Charité undefinedresearch database.