Influence of the early immune monitoring profile on outcome (rejection / induction of tolerance) after liver transplantation

Project 14

Project leaders:

Prof. Dr. rer. nat. Birgit Sawitzki

CharitéUniversitätsmedizin Berlin

CVK: Campus Virchow-Klinikum

Institut für medizinische Immunologie

Postal address:

Augustenburger Platz 1

13353 Berlin

t: +49 30 450 524 136

f: +49 30 450 524 907

Map

Links:

PD Dr. med. Andreas Pascher

CharitéUniversitätsmedizin Berlin

CVK: Campus Virchow-Klinikum

Klinik für Allgemein-, Viszeral und Transplantationschirurgie

Postal address:

Augustenburger Platz 1

13353 Berlin

t: +49 30 450 652 253

f: +49 30 450 55200

Summary

Within the last funding period we could define transcriptional signatures of „operationally“ tolerant transplant patients and we could identify specific surface markers of potentially harmful terminal differentiated memory T cells (TEMRA). Based on these results we will 1) investigate whether persistently high TEMRA frequencies early after transplantation are a barrier for later development of signs of operational tolerance, 2) develop new therapeutic concepts for a selective inactivation/depletion of TEMRA cells and 3) initiate a drug minimization study in potentially operational tolerant liver transplant patients.

Research Database

For more details please use the Charité undefinedresearch database.