Development of tailored protocols for tolerance induction by immunoablation and hematopoietic stem cell transplantation in autoimmune diseases

Project 12

Project leaders:

Dr. med. Tobias Alexander

CharitéUniversitätsmedizin Berlin

CCM: Campus Charité Mitte

Med. Klinik m. S. Rheumatologie und Klin. Immunologie

Postal address:

Charitéplatz 1

10117 Berlin

t: +49 30 450 513 086

f: +49 30 450 513922

Prof. Dr. med. Falk Hiepe

CharitéUniversitätsmedizin Berlin

CCM: Campus Charité Mitte

Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie

Postal address:

Charitéplatz 1

10117 Berlin

t: +49 30 450 513 026

f: +49 30 450 513922

Links:

Prof. Dr. med. Renate Arnold

CharitéUniversitätsmedizin Berlin

CVK: Campus Virchow-Klinikum

Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie

Postal address:

Augustenburger Platz 1

13353 Berlin

t: +49 30 450 553 302

f: +49 30 450 553925

Summary

In a “proof-of-principle” pilot study, we could demonstrate that the “reset of the immune system” with immunoablation followed by transplantation of hematopoietic progenitors (HSCT) can provide long-term and treatment free remission in patients with autoimmune diseases. However, since this curative treatment option is still associated with early infections and relapses of autoimmunity, our aim in the next funding period is to further increase safety and efficacy of the “immune reset” through development of tailored protocols allowing a more selective immune depletion and enhanced T cell competence post-transplantation. In addition, we are aiming at identifying predictive biosignatures for responses after HSCT and we will continue our investigator-initiated controlled trial for the” immune reset” in SLE (ASSIST, NCT00750971)

 

Research Database

For more details please use the Charité undefinedresearch database.