Induction of stable Foxp3+ regulatory T cells

Project 1

Project leader:

Prof. Dr. rer. nat. Alf Hamann

Deutsches Rheuma-Forschungszentrum

CCM: Campus Charité Mitte

Postal address:

Charitéplatz 1

10117 Berlin

t: +49 30 28460 655

f: +49 30 28460 656

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Summary

Goal of the project is to design novel approaches strengthening tolerance towards autoantigens by induction of regulatory T cells (Tregs). For this, modifications of autoantigen-derived peptides are being developed: Peptides coupled to either synthetic carriers or to ligands triggering tolerogenic responses are tested in vitro and in autoimmune models. In addition, the project searches for novel drug candidates able to induce stable Tregs. To improve efficacy of tolerogenic treatments in established disease, combination therapies deleting/inactivating effector cells followed by tolerogenic vaccination will be applied.

Research Database

For more details please use the Charité undefinedresearch database.